2016). Clostridium perfringens is a common clinical Clostridia that produces a large amount of gas, leading to severe emphysema in tissues, which in turn affects blood supply and causes extensive necrosis in the tissues. The neuraminidase (NA) protein of C. perfringens plays an important role in bacterial proliferation and is considered a novel antibacterial drug target. Kim et al. (2014) isolated four isoquinoline alkaloids from RC, namely pseudocoptisine, glaucine, corydaline, and THP and found that they could inhibit the activity of NA and the proliferation of the bacteria. This evidence concerns the gene XK and pulmonary emphysema.