pRNFL atrophy has also been reported in AD, PD, and other neurodegenerative diseases including rare diseases such as Leber’s hereditary optic neuropathy (LHON), OPA1-related dominant optic nerve atrophy (DOA) [36], Wilson`s disease [15], Friedreich`s ataxia [37], and spinocerebellar ataxias [38]. Here, OPA1 is linked to Alzheimer disease.