Cleft palate/lip, dental agenesis and digital bone anomalies were frequently associated with CHH caused by mutations in genes of FGF8 signaling (FGFR1, FGF8, HS6ST1) (Costa-Barbosa et al. 2013; Boehm et al. 2015). Here, FGFR1 is linked to cartilage-hair hypoplasia.