CACNA1S and congenital myopathy with cores: The effects of the MHS-causing mutations in CaV1.1 on caffeine-induced calcium release as well as the predicted effects of several congenital myopathy mutations on CaV1.1-RyR1 coupling corroborate extensive physiological evidence showing the intimate interactions between CaV1.1 and RyR1 within the EC coupling apparatus.