The effects of the MHS-causing mutations in CaV1.1 on caffeine-induced calcium release as well as the predicted effects of several congenital myopathy mutations on CaV1.1-RyR1 coupling corroborate extensive physiological evidence showing the intimate interactions between CaV1.1 and RyR1 within the EC coupling apparatus. Here, RYR1 is linked to congenital myopathy with cores.