Besides, Tregs promote cancer immune evasion by consuming IL-2 and upregulating the expression of multiple immune checkpoints including PD-L1, CTLA-4, T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), V-domain Ig suppressor of T cell activation (VISTA), as well as T-cell immunoreceptor with Ig and ITIM domains (TIGIT) [30–33]. This evidence concerns the gene CD274 and cancer.