For mutant p53 expression, rs3751794 CC genotype (adjusted OR = 3.487;95% CI = 1.024–11.876, P = 0.0457 and rs4843163GC/CC genotype (adjusted OR = 8.877;95% CI = 3.360–23.451, P < 0.0001) was significantly associated with increased epithelial ovarian cancer risk in strong positive group; rs4843396TC/CC genotype was significantly associated with increased epithelial ovarian cancer risk in subgroups of mutant p53 expression (negative/mild expression: adjusted OR = 32.414;95% CI = 4.318–243.321, P = 0.0007; strong positive expression: adjusted OR = 7.239;95% CI = 2.927–17.901, P = 0.0001). This evidence concerns the gene TP53 and ovarian carcinoma.