In APPswe/PSEN1dE9 mice (AD mice) that carry a transgene encoding the 695‐amino‐acid isoform of the human Aβ precursor protein with the Swedish mutation and a mutant human presenilin 1 (PS1‐dE9), which exhibit plaque pathologies similar to those in AD patients, synaptic dysfunctions in the hippocampus, a brain region responsible for learning and memory, reduce the capability of spatial information acquisition (Reiserer, Harrison, Syverud, & McDonald, 2007; Scheff, Price, Schmitt, DeKosky, & Mufson, 2007; Yang et al., 2018). This evidence concerns the gene PSEN1 and Alzheimer disease.