Recently, we have reported that mossy cells (MCs) in the dentate gyrus directly and functionally innervate local somatostatin (SST)‐expressing cells and this innervation controls memory precision (Xinyan Li et al., 2019) (Li, X and Huang, X, manuscript submitted).We thus reasoned that dysfunction of synaptic transmission from MCs to SST cells contributes to memory imprecision in an early stage of AD. The gene discussed is SST; the disease is Alzheimer disease.