CD4 and neoplasm: As previously mentioned, the increased frequencies of Tcm cells (CD4+ and CD8+) and enhanced tumor inflammation profiles in melanoma and non-small cell lung cancer (NSCLC) (Manjarrez-Orduno et al., 2018) are congruent with reports that Tcm cells are the primary repositories of the immunogenic experiences of a lifetime (Wherry et al., 2003; Berger et al., 2008).