TP53 and brain neoplasm: Such a design aimed at testing the potential of the constructed VNP-Laz strain of attenuated Salmonella to deliver a cytotoxic form of Laz to brain tumor cells as well as non-brain tumor cells; confirming the capacity of the surface exposed Laz with its H.8 epitope to disrupt an entry barrier and enabling bacterial cells to enter brain tumor cells and induce apoptosis through interaction with the tumor suppressor protein (p53).