Similarly, TRMT61B has been identified as a differentially expressed gene in a small cohort of Alzheimer’s disease cases, when compared with matched controls52, and knockdown of the drosophila homologue of MRPP3 leads to the loss of locomotive function in Drosophila, similarly to what is seen in Parkinson’s disease27. This evidence concerns the gene TRMT61B and early-onset autosomal dominant Alzheimer disease.