NLRP3 and diabetes mellitus: Furthermore, studies that block IL-1β production using genetic deletion of components of the NLRP3 inflammasome that regulates IL-1β maturation or inhibition of the IL-1β signaling machinery have established a role for this cytokine in promoting insulin resistance and metabolic dysfunction in high fat diet fed mice11,29,34, as well as conditions accelerated by diabetes such as atherosclerosis32,35,36.