ATM and hyperinsulinemic hypoglycemia, familial, 4: In addition to the decrease in IL-1β expression in ATM, we observed an increase in markers of alternatively activated M2 macrophages in the WAT of HFD-fed mice with myeloid deficiency of HIF-1α compared to WT mice, suggesting that loss of HIF-1α leads to a less inflammatory macrophage phenotype in the adipose tissue.