The entire group of T1D patients demonstrated up-regulation of genes related to ER-stress activation (ATF6, PRDX6, GCLC, TXNRD1, SOD2), as well as down-regulation of genes coding proteins involved in glucose transport into the cells (SLC2A11) parallel with glycolysis activation, and up-regulation of carnitine production (SETDB1, DOT1L, SETD2, ALDH9A1). This evidence concerns the gene GCLC and type 1 diabetes mellitus.