In line with this fact, the expression of FH and TEKT1 is lower in semen samples with poor sperm motility (asthenozoospermia)26, indicating that SPANX-A/D family, through the interaction with both proteins FH and TEKT1, could be essential in human spermatozoa to meet energy demands for motility. Here, TEKT1 is linked to Reduced sperm motility.