Adar5G1 aberrant innate immune induction is likely to result from accumulated unedited intracellular dsRNA in Adar5G1, paralleling the mouse Adar1 mutant interferon induction through antiviral dsRNA sensors18, and the human ADAR1 mutant virus infection mimic syndrome Aicardi Goutières Syndrome42 and ADAR1 mutant bilateral striatal neurodegeneration43. The gene discussed is ADAR; the disease is viral infectious disease.