According to previously conducted studies, the manifestation of NUCB2 has been associated with bad prognoses in cases of breast cancer, prostate cancer, clear cell renal cell carcinoma, and endometrial carcinoma.[11,16–18] In particular, in an in vitro study of breast cancer, NUCB2 was reported to play important roles in the migration, proliferation, and invasion of BC cells.[18] To our knowledge, this is the first report to investigate the association between NUCB2 and BC. This evidence concerns the gene NUCB2 and breast cancer.