Economopoulos et al found that MGUS in B-cell NHL was associated with advanced stage and had a negative prognostic factor in aggressive B-cell NHL.[4] Kyle et al reported 430 patients with monoclonal IgM serum protein and found that more than two-thirds of patients died after more than 20 years of follow-up. The gene discussed is CD40LG; the disease is B-cell non-Hodgkin lymphoma.