Taken all these findings together, a potential circRNA-miRNA-mRNA regulatory sub-network in CRC was successively established, containing two pathways hsa_circ_0001955-miR-145-5p-CDK4/MMP12/RAB3IP and hsa_circ_0000977-miR-135b-5p-FOXO1/MBNL1/MEF2C/RECK/PPM1E/TTLL7/PCP4 L1 (Figure 10). The gene discussed is MMP12; the disease is colorectal carcinoma.