By intersection of analytic findings from GEO and TCGA database, we found that three genes (CDK6, MMP12 and RAB3IP) and seven genes (FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7 and PCP4L1) were the potential downstream targets of miR-145-5p and miR-135b-5p in CRC, respectively. The gene discussed is RECK; the disease is colorectal carcinoma.