As presented in Figure 11A–11E and Figure 12A–12I, hsa_circ_0001955, hsa-miR-135b-5p, CDK4, MMP12 and RAB3IP were significantly upregulated whereas hsa_circ_0000977, hsa-miR-145-5p, FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7 and PCP4L1 were markedly downregulated in CRC when compared with normal controls, which were in accordance with GEO and TCGA data. The gene discussed is CDK4; the disease is colorectal carcinoma.