HDAC6 and Sepsis: Additionally, plasma ALT activity (Figure 6E), AST activity (Figure 6F), and plasma BUN (Figure 6G) and creatinine levels (Figure 6H) were dramatically lower in the rats with CLP-induced sepsis treated with Tri A relative to that in the untreated septic rats (37.6 ± 1.67 vs 76.5 ± 2.47, P < 0.01; 47.8 ± 2.87 vs 107.2 ± 5.23, P < 0.01; 51.1 ± 2.11 vs 88.7 ± 3.37, P < 0.01; and 0.28 ± 0.02 vs 0.52 ± 0.05, P < 0.01, respectively), indicating that sepsis-induced hepatic and renal injuries were attenuated by HDAC6 inhibition.