HDAC6 and Sepsis: Additionally, we analyzed the linear correlation between HDAC6 and PHB1 expression and the mitochondrial respiratory control rate, and found that in rats with CLP-induced sepsis, the expression of HDAC6 protein negatively correlated with the mitochondrial respiratory control rate (R2 = 0.7048, P < 0.0001; Figure 4C) while the expression of PHB1 protein positively correlated with this rate (R2 = 0.5580, P < 0.0014; Figure 4B).