The influence of APOE on the prognosis of ALS has been studied to some extent, but the findings so far did not support a strong influence of APOE on disease duration or overall survival.28 We are the first to report that high levels of ApoB and ApoB/ApoAI ratio are indicative of longer survival independently of other known prognostic indicators of ALS. This evidence concerns the gene APOA1 and amyotrophic lateral sclerosis.