APOB and amyotrophic lateral sclerosis: After adjustment for sex, age at diagnosis, site of symptom onset, diagnostic delay, BMI, ALSFRS-R score, and progression rate, a 1-SD increase of TC, LDL-C, LDL-C/HDL-C, ApoB, or ApoB/ApoAI ratio was statistically significantly associated with a lower risk of death after ALS diagnosis (table 3).