If the present findings are indeed true, the protective effect on survival could have contributed partly to the noted positive association between LDL-C, ApoB, and ALS risk, assuming that patients with longer survival have higher levels of LDL-C or ApoB, are more likely to be captured and diagnosed clinically, and are more likely to be recruited in a research study for ALS (e.g., GWAS). This evidence concerns the gene APOB and amyotrophic lateral sclerosis.