Taking advantage of EcSOD−/− mice with intravenous administration of human recombinant EcSOD in vivo, Jung et al. determined the involvement of EcSOD in the control of blood pressure and endothelium-dependent responses in angiotensin II-induced hypertension and renovascular hypertension induced by the two-kidney, one-clip model. The gene discussed is AGT; the disease is Hypertension.