Genetically engineered mice with skeletal muscle-specific overexpression of EcSOD to recapitulate the effects of exercise training showed significantly reduced diabetic cardiomyopathy with reduced cardiac hypertrophy, fibrosis, oxidative damage as well as reduce impairment of cell signaling in a model of late stage type 1 diabetes induced streptozotocin (STZ) injection [11]. Here, SOD3 is linked to cardiac hypertrophy.