First, it is clear that Chd1 deletion alone in the mouse prostate is not sufficient to induce cancer (Augello et al., 2019, Shenoy et al., 2017); however, cancers do emerge after co-deletion of Map3k7 (Rodrigues et al., 2015) or Pten (Augello et al., 2019). Here, CHD1 is linked to cancer.