Based on the above results, we further concluded that strains with the following virulence gene profiles presented significantly stronger biofilm production: 1) fib (+)-hlgv (+)-lukED (+)-sei (-)-sem (-)-seo (-) strains for all the orthopedic isolates (P < 0.001); 2) sei (-)-sem (-)-seo (-) strains for OM isolates (P = 0.006); 3) cna (+)-fib (+)-hlgv (+)-lukED (+)-seb(-)-sed (-) strains for non-OM isolates (P < 0.001) (Fig. 2). Here, SETBP1 is linked to ocular melanoma.