In several studies, BCL2 has been reported to act as a target gene of multiple miRNAs, including miR‐153, miR‐136 and miR‐365.34, 35, 36 BCL2 has also been elucidated to be a target gene of miR‐15b in condylar hyperplasia and liver cancer.37, 38 miR‐15b has been shown to play a role in the development of multidrug resistance in gastric cancer cells, at least in part by modulation of apoptosis via targeting BCL2.39 Consistent with all these findings, we discovered that BCL2 was a target gene of miR‐15b in LUAD, and its expression was mediated by miR‐15b through targeting to its mRNA 3′‐UTR. The gene discussed is BCL2; the disease is liver cancer.