Moreover, IHC results showed that the ratio of Ki-67 positive tumor cells in the γ-ray treatment group was much lower than that in the control group; although the tumor morphology was relatively intact in the NP-BEZ235-Ab group, the ratio of Ki-67 positive tumor cells in this group was not different from that in the γ-ray treatment group; both NP-BEZ235-Ab group and γ-ray treatment group were significantly lower than the control group (Fig. 10f). The gene discussed is MKI67; the disease is neoplasm.