CXCR4 and neoplasm: For example, in a pancreatic cancer model, T cells were typically localized to tumor microenvironment stroma, and the addition of the CXCR4 small-molecule inhibitor AMD3100 led to T cell redistribution and rapid accumulation near tumors, enhancing the antitumor efficacy of an anti-PD-L1 monoclonal antibody combination regimen.13