Furthermore, decreased mRNA levels of canonical YAP target genes were detected in ACADL restored HCC cells, including Connective Tissue Growth Factor (CTGF), Cysteine Rich Angiogenic Inducer 61 (CYR61), and Ankyrin Repeat Domain 1 (ANKRD1) (Fig. 3e). This evidence concerns the gene CCN2 and hepatocellular carcinoma.