In APS and SLE, APL autoantibodies were shown to be associated with antibodies against apolipoprotein A-1 (anti-ApoA-1 IgG), the major fraction of high-density lipoproteins, and such association may be explained by a certain degree of cross-reactivity between APL and anti-ApoA-1 antibodies [3, 4]. Here, APOA1 is linked to systemic lupus erythematosus.