Since the polyclonal anti-ApoA-1 IgG response in humans was shown to be oriented against the last α-helix of c-terminus part of native apoA-1 (amino acids: 220-242) [4, 11, 12], we aimed to determine the prevalence of both anti-ApoA-1 and anti-c-terminus apoA-1 (anti-Ac-terAA1) IgG and their possible relationship with threatened abortion (TA) in a general population of pregnant women. This evidence concerns the gene APOA1 and abortion.