Biomarkers of systemic inflammatory can be categorized into two indices: a differential blood cell count (neutrophil, monocyte, lymphocyte, and platelet) and concentration of specific serum proteins (albumin, C-reactive protein, and fibrinogen) [16], and these indicators have been proven to be related to the prognosis of patients with a variety of cancers including RCC [10, 11, 13, 17, 18]. This evidence concerns the gene CRP and cancer.