The prognostic significance of IL10 in serum or whole tissue homogenate is controversial because a study by De vita et al. suggested that serum IL10 level was a prognostic indicator of advanced NSCLC (66) while studies by Soria et al. demonstrated that patients lacking IL10 expression in early-stage NSCLC have a worse prognosis than those with IL10 expression (67). This evidence concerns the gene IL10 and non-small cell lung carcinoma.