IL10 also drives in vivo lung cancer growth and metastasis by upregulating the CCL2/C-C motif chemokine receptor 2 (CCR2) and C-X-C motif chemokine ligand (CXC3CL1)/C-X3-C motif chemokine receptor 1 (CX3CR1) axis in macrophage-tumor cell crosstalk (20). Here, CCL2 is linked to neoplasm.