For example, MEG3, as a competing endogenous RNA, reduces the invasiveness of human bladder cancer cells by competing with PHLPP2 mRNA for miR-27a (30); MEG3 inhibits the proliferation of epithelial ovarian cancer cells by regulating ATG3 activity and inducing autophagy (31); and MEG3 inhibits the proliferation and invasion of gallbladder cancer by associating with EZH2 and promoting its ubiquitination (32). The gene discussed is EZH2; the disease is urinary bladder cancer.