In the current study, we found a positive correlation between serum vitamin D concentration and MEG3 expression in patients with CRC (Figure 5A); to the best of our knowledge, we are the first to document a correlation between MEG3 and serum vitamin D. In addition, we showed that MEG3 can be induced by vitamin D via VDR transcription factor (Figures 5B–D), which is consistent with previous research (10). Here, VDR is linked to colorectal carcinoma.