POU5F1 and neoplasm: In addition, overexpression of OCT3/4B in the CC SiHa cell line favors cell proliferation; tumorigenesis by inhibiting apoptosis; enhanced angiogenesis by positive regulation of CD34, VEGF, HIF-1α, and IL-6; tumor cell migration to the surrounding tissue through the upregulation of MMP2 and MMP9; and induction of EMT (46).