We then used clinical tissues to further analyze the expression profiles of the above three genes in ccRCC patients, and found that METTL14 and HNRNPA2B1 showed higher expressions in normal samples than in tumor tissues, while METTL3 expression in tumor tissues were higher than that of normal tissues, which was in accordance with our analysis. This evidence concerns the gene METTL14 and nonpapillary renal cell carcinoma.