In SFG, MAPT, which codes the tau protein and whose over-expression can result in the self-assembly of axonal tangles, had 41 DCE partners; APOE, associated with the common late onset familial and sporadic forms of AD, had 24; APP, which codes amyloid- β protein precursor (AβPP) and whose proteolysis leads to the formation of Aβ, a primary component found in the brain of AD patients, had 10 (Table S9). This evidence concerns the gene APOE and Alzheimer disease.