Recently it has been shown, based on experiments in which Aβ-expressing, APP knockout, and mouse models, as well as worm and mammalian cell models were infected with pathogens including C. albicans and S. Typhimurium, that Aβ may be a natural antibiotic that protects the brain from bacterial infection through the adhesion to and agglutination of invading microbes by oligomerized and fibrillized Aβ (Kumar et al., 2016). This evidence concerns the gene APP and bacterial infectious disease.