In a comprehensive study, the authors of the AG dataset presented evidence suggesting that the transcription factor REST (also known as neuron-restrictive silencer factor, NRSF) is normally induced and acts as a universal feature of normal ageing in human cortical and hippocampal neurons, and a neuroprotective modulator by repressing genes that promote cell death and the pathology of AD, and confers oxidative stress resistance and protects against toxic insults, such as Aβ oligomers and tau phosphorylation, associated with AD, but is lost in mild cognitive impairment and AD (Lu et al., 2014). This evidence concerns the gene MAPT and Alzheimer disease.