The relevant genes included LSM5, PCBP2, CELF4, UTP20, SP1, POLR3D, etc. The KEGG pathways, RNA degradation and spliceosome, were also upregulated and involving genes included LSM5, SRSF3, HNRNPC, PCBP1, SNRPB, CDC5L, etc. Most of genes mentioned above also are related to the carcinogenesis or metastasis of cancer. This evidence concerns the gene POLR3D and cancer.