However, GRß mRNA transcript works as a regulator of GRα mRNA transcript activity, and disruption of the GRα/GRß ratio may be related to resistance to glucocorticoids in ITP (Hamed et al., 2015), as this ratio predicts how the cell will respond to glucocorticoid treatments. This evidence concerns the gene NR3C1 and autoimmune thrombocytopenic purpura.