NOS2 and colorectal adenocarcinoma: Chemo-preventive activity of chitooligosaccharides in human colorectal adenocarcinoma cells line (HT-29) was reported to be the result of regulation activity of intracellular antioxidant enzymes GSH and GR.81 It was also observed that chitooligosaccharides inhibited proinflammatory cytokine-mediated nitric oxide (NO•) production and inducible NO synthase (iNOS), leading to a decrease in proliferation of HT-29.82