MAPT and tauopathy: Phosphorylated tau and its assemblies have been mechanistically implicated in diverse tauopathies as pathological culprits, and studies on different lines of tau transgenic mice have indicated crucial roles played by soluble but misfolded tau species comprised of monomers and oligomers with pathological conformations and posttranslational modifications in neurodegenerative pathogenesis30,41,42.