The PGC-like characteristics of tumor cells20,23, which are induced by loss of p53 based on our earlier study9, might be key determinants in empowering a real seed for liver metastasis, lending a strong support of the embryonal/gametogenesis theory of tumors, which points to tumor metastasis corresponding to PGC migratory properties24. The gene discussed is TP53; the disease is neoplasm.