Moreover, a series of other germ cell-specific markers, including Nanog, SSEA1, Sox2, Prdm14, Stellar, Ifitm3, Nanos3, and DAZL were highly expressed in PGC-like tumor cells (Fig. 1d), but rarely detected in the full differentiated somatic cell-like subpopulation (Supplementary Fig. S1a), further validating their similarity to natural PGCs10. This evidence concerns the gene NANOG and neoplasm.