Moreover, JARID1A has been identified as a fusion partner of Nucleoporin-98 (NUP98, a common fusion partner found in many leukaemias) in a subset of acute myeloid leukaemia (AML) patients in which chromosomal translocation of NUP98 resulted in fusion of its amino terminus with the C-terminus PHD motif (PHD3) of JARID1A [7] (figure 1). The gene discussed is EGLN3; the disease is acute myeloid leukemia.