Given the documented interactions of JARID1A with LMO2, JARID1A's implication in AML and the fact that many protein partners of SCL, such as mSin3A and pRB [22,26], are also interaction partners of JARID1A [27,28], we set out to investigate a potential physical interaction between JARID1A and the pentameric protein complex to gain insights into JARID1A's function in haematopoiesis. The gene discussed is KDM5A; the disease is acute myeloid leukemia.