Moreover, JARID1A has been identified as a fusion partner of Nucleoporin-98 (NUP98, a common fusion partner found in many leukaemias) in a subset of acute myeloid leukaemia (AML) patients in which chromosomal translocation of NUP98 resulted in fusion of its amino terminus with the C-terminus PHD motif (PHD3) of JARID1A [7] (figure 1). Here, KDM5A is linked to leukemia.