To address this hypothesis, we measured MCP-1 transcription in explanted cirrhotic livers and MCP-1 levels in portal and hepatic venous blood from patients with decompensated cirrhosis at transjugular intrahepatic portosystemic shunt insertion (TIPS), and further confirmed our findings in animal models of cirrhosis and ACLF. This evidence concerns the gene CCL2 and Cirrhosis.