NLRP3 and obesity due to melanocortin 4 receptor deficiency: In the present study, we observed that the NLRP3 inflammosame, which plays an important role in the development of obesity-related cardiac dysfunction and remodeling (Sokolova et al., 2019), was either absent or only very weakly expressed in the cardiomyocytes of lean mice (Figure 4A), whereas ob/ob mice showed moderate expression of this pro-inflammatory marker in the cytoplasm of cardiomyocytes (Figure 4B).