MAPT and Alzheimer disease: The deposits of Aβ and the neurofibrillary tangles composed of hyperphosphorylated tau protein (pTau) are the neuropathological hallmarks of AD, and tauopathy is enhanced following Aβ amyloidosis (Hardy and Selkoe, 2002; Perrin et al., 2009; Hashimoto et al., 2019).