MAPT and Alzheimer disease: These findings in this mouse AD model represent characteristics of human AD pathological findings and support the amyloid cascade theory of AD, in which accumulation of pathogenic Aβ induces amyloid plaques, hyperphosphorylation of tau (tauopathy), and microglial activation (Hardy and Selkoe, 2002; Selkoe and Hardy, 2016; Sasaguri et al., 2017; Edwards, 2019; Hashimoto et al., 2019).