Furthermore, reduction of gamma oscillation associated with its dysfunction or phenotype loss was reported in human AD patients (Stam et al., 2002) and human amyloid precursor protein (hAPP) transgenic mice (Verret et al., 2012), which may be implicated in cognitive deficits in the hAPP mice and possibly in AD patients (Verret et al., 2012). Here, APP is linked to Alzheimer disease.