AR and Huntington disease: Polyglutamine (polyQ) expansions in unrelated proteins and consequent intracellular accumulation of the mutant protein in inclusion bodies is the underlying cause of a number of inherited rare neurodegenerative disorders, including Huntington’s disease (HD) (polyQ expansion in the huntingtin protein), spinal and bulbar muscular atrophy (SBMA) (polyQ expansion in the androgen receptor protein), and some forms of spinocerebellar ataxias (polyQ expansion in ataxin protein) (Perutz, 1999).