SIRT1 and early-onset autosomal dominant Alzheimer disease: Accumulating evidence demonstrated that Sirt1 plays an important role for neuroprotection in several models of neurodegenerative diseases, such as Alzheimer’s disease (AD) (Fujita and Yamashita, 2018), while the level of hippocampal Sirt1 were significantly decreased in patients with AD (Cao et al., 2018).