ME2 and dysplasia: Indeed, a high expression level of ME2 was observed in human primary OSCC tissue (n = 176) compared with normal oral mucosal tissue (n = 42, P < 0.05, Fig. 1C), whereas the difference in the expression level of ME2 between the OSCC and dysplasia tissues was not significant (n = 69, P > 0.05, Fig. 1C).