Because we have discovered that PFD may inhibit proliferation, migration and collagen contraction in human tenon's fibroblasts by down regulating TGF-β signaling 20, and prevent scaring by inhibiting TGF-β and TIMP-1 pathways in experimental glaucoma surgery 21, we investigated the effects of PFD on proliferation, migration and collagen contraction of cultured human pterygium fibroblasts (HPFs), and further explored the potential molecular mechanisms. Here, TIMP1 is linked to pterygium.