Among the full cohort, patients with hypertension were older, with a higher prevalence of smokers, DM, LVH, eGFR < 60 mL/min/1.73 m2, and abnormal cIMT than the normotensive patients, and higher mean BMI, fasting glucose, serum phosphate, triglyceride, proteinuria, serum Scr, uric acid, serum cystatin C, nighttime urinary sodium excretion, night/day urinary sodium excretion ratio, LVMI, and cIMT. The gene discussed is CST3; the disease is hypertensive disorder.