After adjustment for factors significantly associated with TOD variables in the univariate regression analysis, including age, sex, DM, current smoking status, alcohol intake, BMI, hemoglobin, albumin, calcium, phosphate, serum fasting glucose, cholesterol, triglycerides, HDL-C, LDL-C, uric acid, proteinuria and eGFR, the tertile 3 group remained independently associated with hypertension, lower eGFR, and LVH, but not with abnormal cIMT (Table 5). The gene discussed is ALB; the disease is hypertensive disorder.