In recent years, new interest in the polymorphisms of FUT3 has been raised by genome-wide association studies (GWASs), which have suggested inactivating polymorphisms (T59G, G508A) of the gene to be associated with the prevalence of ulcerative colitis (UC)26, Crohn’s disease (CD)27 and coronary artery disease28,29. Here, FUT3 is linked to Cowden disease.