The present study attempted to reveal whether the interaction between CO and the cluster of the other four MetS risk factors namely raised blood pressure, raised triglycerides, raised fasting blood glucose and reduced HDL cholesterol could alter the circulatory peptide profile related to ghrelin signalling and GH/IGF-1 axis including UnAG, AG, obestatin, nesfatin-1, GH and IGF-1. This evidence concerns the gene GHRL and metabolic syndrome.