DDT also increases Aβ levels in H4 glioma cells with a APPSwe transgene via elevation of APP and BACE1, while decreasing the levels of Aβ-clearing ATP-binding cassette transporter A1 (ABCA1) and inhibiting the activity of Aβ-degrading insulin-degrading enzyme (IDE) [63]. The gene discussed is IDE; the disease is central nervous system cancer.